Dr. Symons and team members compared plaque measurement reproducibility (scan-rescan) on 2 state-of-the-art CT scanners. Group (1) of 20 patients had rescan within 30 days on same scanner, while group 2 had rescan on different scanner. Plaque volumes were analyze with Medis’ QAngio CT Research Edition software. Conclusions: State-of-the-art CCTA shows excellent total, calcified and non-calcified coronary plaque reproducibility, especially with the same CT scanner. CCTA is a valid tool to reliably assess change in coronary plaque volume in both research and clinical routine.