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The team of Dr Kuijpers (Bronovo Hospital, the Hague) and Prof Oudkerk (UMCG Groningen) investigated the effect of caffeine intake on adenosine-stress myocardial perfusion.

They used the T1-module of QMass and concluded that caffeine intake inverts the adenosine effect during stress perfusion CMR as measured by T1 mapping. Therefore, the ∆T1 (rest T1 minus T1 stress) can be used as a benchmark for the validity of the stress induction by adenosine at cardiac MR perfusion studies